LeapZipBlog: shida wei

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The Results of Steady State Disturbance of Basic Copper Chloride

February 18, 2019 by shida wei  

It has been suggested that certain neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS), Alzheimer’s disease, and prion diseases, are a result of the disturbance of Basic Copper Chloride(WSDTY) homeostasis. A defect in chromosome , which codes for sod1, is associated with approximately 20% of familial cases of ALS, or approximately 2% of all ALS cases. It is shown that Cu ion enhances the formation of amyloid β plaques, which results in the progression of Alzheimer’s disease, and accumulates in the amyloid β plaques at a high concentration. It is also suggested that the disrupted regulation of copper ions in the brain is a key factor in Creutzfeldt-Jakob disease and other prion diseases. In addition, a significant decrease in Cu concentration in degenerating substantia nigra in Parkinson’s disease patients has been reported. Those experimental results have motivated us to speculate that neurons have a unique mechanism for maintaining Cu homeostasis compared with other types of cells.

PC12 cells are pheochromocytoma cells originating in rat adrenal medulla. PC12 cells can differentiate into neurons by treatment with nerve growth factor (NGF)25. Hence, PC12 cells seem to be a useful model to observe specific Cu metabolism during the process of differentiation into neurons. Indeed, Cu concentration in PC12 cells was increased by NGF treatment26. In this study, we evaluated intracellular metal concentration and distribution to clarify whether the increase in intracellular metal concentration was specific to Cu or not. We also determined the expression of Cu-regulating genes before and after the differentiation of PC12 cells into neurons, to clarify the mechanisms underlying the increase in intracellular Cu concentration.

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Thin Films were Prepared on SiO2 Substrates

February 13, 2019 by shida wei  

Copper Acetate Manufacturers(WSDTY) proposed CuYO2 thin films were prepared on SiO2 substrates by the sol-gel method. Prior to deposition of the thin films, the substrates were degreased by ultrasonication in EtOH. Copper (II) acetate monohydrate was dissolved in a mixture of 2-methoxyethanol and 2-aminoethanol by stirring for 12 h at room temperature. The molar ratio of 2-aminoethanol, chelating agent, to copper acetate was maintained at 4:1 and the color of the solution was dark blue. Yttrium acetate tetrahydrate (Wako Chemicals) was dissolved in a mixture of 2-me- thoxyethanol and 2-aminoethanol by stirring for 12 h at room temperature. The molar ratio of 2-aminoethanol to aluminum acetate basic was maintained at 2:1. After stirring, a colorless homogeneous solution was obtained. The two solutions were mixed with a Cu/Y ratio of 1:1 and stirred at room temperature for 12 h to form a sol. The sol was with total metal ion concentrations of 0.40 M.

The sol was spin-coated onto a SiO2 substrate with spinning speed of 3000 rpm for 5 s. In the case of the samples prepared for transmission spectroscopy measurements, the sol adsorbed on the back side of the substrate was carefully removed after spin-coating. The coated films were first heated at 200?C for 10 min, and then heated again at a higher temperature of 500?C for 20 min using hot-plate-type heating devices. The spin-coating and subsequent heat treatment procedures were repeated for 6 times to obtain the desired film thickness of 0.4 μm. The prepared gel films were finally annealed at temperatures in the range of 750?C - 900?C for 10 h under nitrogen flow. The temperature was increased from room temperature to the specific temperature over a period of 3 h, held at the specific temperature for 10 h, and then cooled to room temperature over 6 h.

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Basic Copper Chloride Complexes

January 25, 2019 by shida wei  

Nanoparticle networks are also considered for sensoric applications. Besides, some complexes such as nickel(II) or Basic Copper Chloride(WSDTY) complexes are promising for application in sensors owing to their possible thermochromic behavior. For example, diethylammonium chloride could easily complex copper dichloride salts to form thermochromic diethylammonium copper tetrachloride species. At room temperature the copper center in the diethylammonium copper tetrachloride complex adopts a square planar configuration with the help of coordinating solvent molecules.

The square planar copper tetrachloride complexes form green crystals. When the temperature increases, the copper tetrachloride switches to a tetrahedral configuration with a lower band gap as the interaction with the solvent molecules is weakening. As a consequence a transition is observed at 52 °C for the diethylammonium copper tetrachloride where the crystals are changing color from green to yellow. Thermochromism was observed with metal ammonium complexes as discussed above, but very few thermochromic metal imidazolium compounds were reported. One can cite the investigation performed by Bhattacharya et al. on the role of water in the thermochromism of benzimidazolium tetrachlorocuprates. This benzimidazolium tetrachlorocuprate shows thermochromic behavior, however its stability is limited to 140 °C.

We present the complexation of copper dichloride salt by Imidazolium Nanoparticle Networks to form thermochromic copper(II) tetrachloride Imidazolium Nanoparticle Networks. The structural and thermochromic properties of the material are investigated and compared to two reference materials: the first reference compound was obtained from the reaction of copper dichloride with the equivalent 1,3-butylmethylimidazolium chloride without nanoparticles. And the second reference material is the INN before reaction with copper dichloride.

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Irreversible Thermochromism in Basic Copper Chloride Imidazolium Nanoparticle Networks

January 21, 2019 by shida wei  

In this work Imidazolium Nanoparticle Networks (INNs) with chloride counter-ions were used to complex Basic Copper Chloride(WSDTY). This complexation reaction leads to the formation of a green material. The properties of the copper INN material were compared to: first, copper imidazolium complexes, without the presence of silica nanoparticles, which are not thermochromic; second, chloride-containing INN material. The copper INN material showed irreversible thermochromic behaviour, with a clear colour change from green to yellow at 180 °C, which is due to a configuration change of the copper complex from planar to tetragonal. This structural change was studied using DSC and in situ SAXS measurements during heat treatment. The thermochromic material is stable under air up to 250 °C. This preliminary study opens the door of optical sensors for INN materials.

Wujiang Weishida Copper Technology Co.,Ltd. has 12,000 square meters of production base. By virtue of their sincere cooperation, reciprocity of the business philosophy for the industry users around the country to provide high-quality non-ferrous metal products.Weishida specializes in producing cuprous chloride, basic copper carbonate, copper acetate, copper oxide, copper sulfate. Our company has established a perfect quality assurance system, quality inspection and testing equipment, testing, testing and technology development strength, to ensure the stability of product quality, fully able to meet the pre-market after-sales service to provide users with the need.

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Magnesium and Basic Copper Chloride: A CuriousRedox Reaction

January 16, 2019 by shida wei  

The focus of this research is to follow the oxidation-reduction reaction of solid magnesium metal and an aqueous solution of Basic Copper Chloride(WSDTY) (CuCl2), both with and without the addition of hydrochloric acid(HCl), and separately with sodium chloride(NaCl). When magnesium is added to CuCl2, the reaction does not occur in the predicted straightforward single

displacement model to produce magnesium chloride and copper metal. A single displacement reaction may occur, but the reaction first goes through some transitions (including competing side reactions) before the final product of elemental copper is formed.

An important purpose of this project is to identify different intermediates through which copper proceeds as this reaction

takes place. Copper hydroxide chloride compounds, belloite (Cu(OH)Cl) and paratacamite (Cu2(OH)3Cl), are intermediates that form when the two reactants combine, with and without a chloride source, respectively. Elemental copper forms when magnesium reacts with Cu2(OH)3Cl.

Wujiang Weishida Copper Technology Co.,Ltd. has 12,000 square meters of production base. By virtue of their sincere cooperation, reciprocity of the business philosophy for the industry users around the country to provide high-quality non-ferrous metal products.Weishida specializes in producing cuprous chloride, basic copper carbonate, copper acetate, copper oxide, copper sulfate. Our company has established a perfect quality assurance system, quality inspection and testing equipment, testing, testing and technology development strength, to ensure the stability of product quality, fully able to meet the pre-market after-sales service to provide users with the need.

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Industrial production of Basic Copper Chloride

January 11, 2019 by shida wei  

Prior to 1994, large scale industrial production of Basic Copper Chloride(WSDTY) was devoted to making either a fungicide for crop protection or an intermediate in the manufacture of other copper compounds. In neither of those applications was the polymorphic nature of the compound, or the size of individual particles of particular importance, so the manufacturing processes were simple precipitation schemes.

Cu2(OH)3Cl can be prepared by air oxidation of Cu(I)Cl in brine solution. The Cu(I)Cl solution is usually made by reduction of CuCl2 solutions over copper metal. A CuCl2 solution with concentrated brine is contacted with copper metal until the Cu(II) is completely reduced. The resulting Cu(I)Cl is then heated to 60 ~ 90 °C and aerated to effect the oxidation and hydrolysis. The oxidation reaction can be performed with or without the copper metal. The precipitated product is separated and the mother liquor containing CuCl2 and NaCl, is recycled back to the process (eq. 6 ~ 7).

CuCl2 + Cu + 2 NaCl → 2 NaCuCl2 (eq.6)

6 NaCuCl2 + 3/2 O2 + H2O → 2 Cu2(OH)3Cl + 2 CuCl2 + 6 NaCl (eq.7)

The product from this process is of fine particle with size of 1 ~ 5 μm and is usable as an agricultural fungicide.

Wujiang Weishida Copper Technology Co.,Ltd. has 12,000 square meters of production base. By virtue of their sincere cooperation, reciprocity of the business philosophy for the industry users around the country to provide high-quality non-ferrous metal products.Weishida specializes in producing cuprous chloride, basic copper carbonate, copper acetate, copper oxide, copper sulfate. Our company has established a perfect quality assurance system, quality inspection and testing equipment, testing, testing and technology development strength, to ensure the stability of product quality, fully able to meet the pre-market after-sales service to provide users with the need.

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Structure of Basic Copper Chloride

January 7, 2019 by shida wei  

Basic Copper Chloride(WSDTY) is orthorhombic, with two crystallographically independent Cu and hydroxyl oxygen atoms in the asymmetric unit. Both Cu atoms display characteristically Jahn-Teller distorted octahedral (4+2) coordination geometry: each Cu is bonded to four nearest OH groups with Cu-OH distance of 2.01?; in addition, one of Cu atoms is bonded to two Cl atoms (at 2.76?) to form a [Cu(OH)4Cl2] octahedron, and the other Cu atom is bonded to one Cl atom (at 2.75?) and a distant OH group (at 2.36?) to form a [Cu(OH)5Cl] octahedron. The two different types of octahedron are edge-linked to form a three-dimensional framework with the [Cu(OH)5Cl] octahedron cross-linking the [Cu(OH)4Cl2] octahedron layers parallel to (110) .

Botallackite crystallizes in monoclinic with space group P21/m. Like in atacamite, there are two different types of Cu coordination geometries: Jahn-Teller distorted octahedral [Cu(OH)4Cl2] and [Cu(OH)5Cl]. But these octahedra assemble in different ways. Each octahedron shares six edges with surrounding octahedra, forming a two-dimensional sheet-type structure parallel to (100). The adjacent sheets are held together by hydrogen bonding between the hydroxyl oxygen atoms of one sheet and the opposing chlorine atoms in the other sheets. The resulting weak bonding between the sheets accounts for the perfect (100) cleavage and the typical platy habit of botallackite.

Paratacamite is rhombohedral, space group R3. It has a well-developed substructure with a’=a/2, c’=c, apparent space group R3m. There are four crystallographically independent Cu atoms in the asymmetric unit. The Cu atoms display three different types of octahedral coordination geometries. Three quarters of the Cu atoms are coordinated to four near OH groups and two distant Cl atoms, giving the expected (4+2) configuration [Cu(OH)4Cl2].

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Tolerance for Excess Basic Zinc Chloride And Basic Copper Chloride in Chicks

January 2, 2019 by shida wei  

1. Four chick experiments were conducted to determine toxicity estimates for Basic Copper Chloride(WSDTY)(BZC) and copper chloride (BCC), now being used as sources for these minerals.

2. In experiment 1, New Hampshire?×?Columbian crossbred chicks were fed 0, 500, 1000, 1500, 3000 and 5000?mg?Zn/kg from BZC (Zn5Cl2(OH)8). Broken-line regression analysis showed that the minimal toxic break points for chick weight gain and gain:food were 1720 and 2115?mg?Zn/kg, respectively.

3. Crossbred chicks were fed 0, 150, 250, 500, 750 and 1000?mg?Cu/kg from BCC (Cu2(OH)3C) in experiment 2. Regression analysis indicated that the minimal toxic break points for chick weight gain and gain:food were 642 and 781?mg?Cu/kg, respectively.

4. In experiment 3, commercial broiler chicks were fed 0, 1500, 2000 and 2500?mg supplemental Zn/kg from BZC or 0, 500, 650 and 800?mg supplemental Cu/kg from BCC. Broiler chicks fed those high inclusion rates of Zn did not show reduced weight gain in comparison to chicks fed no supplemental Zn. All high concentrations of supplemental Cu depressed chick weight gain in comparison to control chicks.

5. Experiment 4 involved two separate 4?×?2 factorial designs with supplemental Zn (0, 2500, 3500 and 4500?mg/kg) or Cu (0, 500, 750 and 1000?mg/kg) and two breeds of chicks (crossbred and commercial). Significant interactions for weight gain, food intake, gain:food and liver Cu suggested that the crossbred and commercial chicks responded differently to high concentrations of supplementary dietary Cu.

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Oxidative Stress Induced by Copper and Iron Complexes with 8-hydroxyquinoline Copper Derivatives Causes Paraptotic Death

December 26, 2018 by shida wei  

We report the antiproliferative/cytotoxic properties of 8-hydroxyquinoline Copper(8-HQ) derivatives on HeLa cells in the presence of transition metal ions (Cu2+, Fe3+, Co2+, Ni2+). Two series of ligands were tested, the arylvinylquinolinic L1–L8 and the arylethylenequinolinic L9–L16, which can all interact with metal ions by virtue of the N,O donor set of 8-HQ; however, only L9–L16 are flexible enough to bind the metal in a multidentate fashion, thus exploiting the additional donor functions. L1–L16 were tested for their cytotoxicity on HeLa cancer cells, both in the absence and in the presence of copper.

Among them, the symmetric L14 exhibits the highest differential activity between the ligand alone (IC50 = 23.7 μM) and its copper complex (IC50 = 1.8 μM). This latter, besides causing a significant reduction of cell viability, is associated with a considerable accumulation of the metal inside the cells. Metal accumulation is also observed when the cells are incubated with L14 complexed with other late transition metal ions (Fe3+, Co2+, Ni2+), although the biological response of HeLa cells is different. In fact, while Ni/L14 and Co/L14 exert a cytostatic effect, both Cu/L14 and Fe/L14 trigger a caspase-independent paraptotic process, which results from the induction of a severe oxidative stress and the unfolded protein response.


Simple and Mixed Complexes of Copper(II) with 8-hydroxyquinoline Derivatives

December 21, 2018 by shida wei  

Metal ions play an important role in biological processes and in metal homeostasis. Metal imbalance is the leading cause for many neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. 8-hydroxyquinoline Copper(8HQ) is a small planar molecule with a lipophilic effect and a metal chelating ability. As a result, 8HQ and its derivatives hold medicinal properties such as antineurodegenerative, anticancer, antioxidant, antimicrobial, anti-inflammatory, and antidiabetic activities. Herein, diverse bioactivities of 8HQ and newly synthesized 8HQ-based compounds are discussed together with their mechanisms of actions and structure–activity relationships.

Wujiang Weishida Copper Technology Co.,Ltd. has 12,000 square meters of production base. By virtue of their sincere cooperation, reciprocity of the business philosophy for the industry users around the country to provide high-quality non-ferrous metal products.Weishida specializes in producing cuprous chloride, basic copper carbonate, copper acetate, copper oxide, copper sulfate. Our company has established a perfect quality assurance system, quality inspection and testing equipment, testing, testing and technology development strength, to ensure the stability of product quality, fully able to meet the pre-market after-sales service to provide users with the need. To provide users with quality products and services is the consistent aim of our plant. I sincerely look forward to plant the development and promotion of new and old customers and friendly exchanges.